Vidalista 80 (tadalafil 80 mg) can stay in your system for up to 36–48 hours, which is why tadalafil is often called the “weekend pill.” Tadalafil has a long half-life of about 17.5 hours, meaning it takes that long for half of the drug to be eliminated from the body. In most healthy adults, the drug’s effects on erectile function may last 24 to 36 hours, while small amounts can remain detectable for 2–3 days, depending on metabolism, age, liver or kidney function, and dose. Because 80 mg is a high dose, clearance may take longer and the risk of side effects—such as headache, flushing, low blood pressure, or muscle pain—is higher, so it should only be used under medical guidance and not combined with nitrates or excessive alcohol.
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